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KMID : 0043319810040010019
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Archives of Pharmacal Research
1981 Volume.4 No. 1 p.19 ~ p.24
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Ibuprofenlysine Binding to Human and Bovine Serum Albumin Using a Fluorescence Probe Technique
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Kim CK
Cha HS/Kim YB/Yu BS
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Abstract
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The possibility of using a fluorescence probe technique for the study of ibuprofenlysine binding to human and bovine serum albumin was investigated. 1-anilino-8-naphalenesulfonate was used as the probe. The number of binding sites of human and bovine serum albumins for ibuprofenlysine appears to be 4 and 2, respectively. By using this technique, the association constants were found to be 1.533 X 104M-1 and 2.238 X 104M-1, respectively.
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